Endocrine Abstracts

The cytosolic calcium concentration is regulated by calcium-processing proteins such as transient receptor potential cation channel subfamily V member 5 (TRPV5), TRPV6, sodium-calcium exchanger 1 (NCX1) and plasma membrane Ca2+ ATPase 1 (PMCA1). Those calcium-processing proteins are important for physiological functions in the brain. The effects of steroid hormones on calcium-processing protein expressions in the brains are undescribed. Thus, the effects of steroid ...

Calbindin-D9k (CaBP-9k), one of the major calcium-binding and calcium-buffering proteins, is important in the physiological functioning of organs. The neuroanatomical localization of CaBP-9k in the rodent brain has not been reported; thus, this study investigated the neuroanatomical distribution of CaBP-9k and the regulation of CaBP-9k expression on steroid hormones in the immature rat brain. To confirm the influence of steroid hormones on CaBP-9k expression, immatu...

Introduction: Hypoxia-inducible factors (HIF) are the key transcription factor induced by hypoxic condition, which regulate expression of specific target genes including angiogenic factors, erythropoietin, glucose transporters, and glycolytic enzymes. Recently, many studies connected to intracellular calcium levels and regulation of HIF-1α protein level. Calbindin-D9k is a cytosolic calcium-binding protein and compensate with other calcium transporter protein f...

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...

Introduction: Phthalates are chemicals used to improve the plasticity of industrial polymers and used in commercial products such as toys, paints, packaging materials, medicals devices and personal care items. Phthalates, endocrine disrupting chemicals, have been documented to cause adverse effects to the human health such as breast cancer in female, reduced uroogenital distance and changed the expression of steroidogenesis and folliculogenessis. In this study, we investigated...

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

Miscarriage is a very common occurrence in humans, in which blastocyst implantation failure in naturally-occurring and assisted human reproduction occurs in up to 2/3 of all cases. Calcium (Ca2+) has been showed to involve in many cellular signal transduction pathways as well as regulation of cell adhesion, which is necessary for the physiology process of endometrial epithelial cell transformation and stromal cell decidualization during embryo implantation. Previous...

Introduction: Calbindin-D9k is a 9 kDa polypeptide expressed in the mammalian intestine, uterus, and pituitary gland. Calbindin-D9k increase Ca2+ absorption by buffering intracellular Ca2+. The intracellular concentration of calcium is regulated by calcium related proteins such as calbindin-D9k, TRPV1 and PMCA1. The regulatory effect of steroid hormones and glucocorticoids on calbindin-D9k, TRPV1 and PMCA1 expre...